| Pair Name | Sulforaphane, Clofarabine | ||
| Phytochemical Name | Sulforaphane (PubChem CID: 5350 ) | ||
| Anticancer drug Name | Clofarabine (PubChem CID: 119182 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Sulforaphane, Clofarabine | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | CDKN2A | hsa1029 |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| Result | We showed that clofarabine in combination with sulforaphane, a phytochemical from cruciferous vegetables, significantly reactivates DNA methylation-silenced CDKN2A tumour suppressor and inhibits cancer cell growth at a non-invasive breast cancer stage. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation. Nucleosides Nucleotides Nucleic Acids. 2018;37(5):280-289. doi: 10.1080/15257770.2018.1453075. | Click |
